Redmond has issued 16 bulletins to fix a whopping 49 vulnerabilities that affect all versions of Windows from XP to 7.
Four of the bulletins have been rated critical, two moderate, and the rest - important.
The wide-ranging update also patches various security flaws in Microsoft's popular Office suite, ranging from XP to 2010.
"The number of vulnerabilities in itself is noteworthy but two items from this crop of patches are especially notable," explained Jonathan Leopando of TrendMicro.
"First of all, Mac users have something to worry about as well, as Office 2004 and 2008 and the OpenXML File Format Converter for Mac are covered by two bulletins.
"Server applications are also part of this month's fixes, as several key components of the SharePoint collaboration suite have also been patched, while Office Web Apps has also been covered."
Other notable patched vulnerabilities include:
Additional information on the above-mentioned vulnerabilities and their respective patches can be found here.