Lack of deep sleep in elderly may prevent brain from storing memories
The connection between poor sleep, memory loss and brain deterioration as humans age has been somewhat of an elusive study over the years.
Fortunately, researchers at the University of California, Berkeley, recently identified a link between the classic maladies of old age.
Indeed, UC Berkeley neuroscientists have confirmed the slow brain waves generated during the deep, restorative sleep we typically experience in youth play a key role in transporting memories from the hippocampus – which provides short-term storage for memories – to the prefrontal cortex's longer term "hard drive."
However, in older adults, memories may be getting stuck in the hippocampus due to the poor quality of deep 'slow wave' sleep, and are then overwritten by new memories.
"What we have discovered is a dysfunctional pathway that helps explain the relationship between brain deterioration, sleep disruption and memory loss as we get older – and with that, a potentially new treatment avenue," explained UC Berkeley sleep researcher Matthew Walker, an associate professor of psychology and neuroscience at UC Berkeley.
The latest findings offer new insights on some of the forgetfulness common to the elderly that includes difficulty remembering people's names.
"When we are young, we have deep sleep that helps the brain store and retain new facts and information," said Walker. "But as we get older, the quality of our sleep deteriorates and prevents those memories from being saved by the brain at night."
To be sure, healthy adults typically spend one-quarter of the night in deep, non-rapid-eye-movement (REM) sleep. Slow waves are generated by the brain's middle frontal lobe, and deterioration of this frontal region of the brain in elderly people is linked to their failure to generate deep sleep.
The discovery that slow waves in the frontal brain help strengthen memories paves the way for therapeutic treatments for memory loss in the elderly, such as transcranial direct current stimulation or pharmaceutical remedies. For example, in an earlier study, neuroscientists in Germany successfully used electrical stimulation of the brain in young adults to enhance deep sleep and doubled their overnight memory.
For the UC Berkeley study, Bryce Mander and fellow researchers tested the memory of 18 healthy young adults (mostly in their 20s) and 15 healthy older adults (primarily in their 70s) after a full night's sleep. Before going to bed, participants learned and were tested on 120 word sets that taxed their memories.
As they slept, an electroencephalographic (EEG) machine measured their brain wave activity. The next morning, they were tested again on the word pairs, but this time while undergoing functional and structural Magnetic Resonance Imaging (fMRI) scans.
In older adults, the results showed a clear link between the degree of brain deterioration in the middle frontal lobe and the severity of impaired "slow wave activity" during sleep. On average, the quality of their deep sleep was 75 percent lower than that of the younger participants, and their memory of the word pairs the next day was 55 percent worse.
Meanwhile, in younger adults, brain scans showed that deep sleep had efficiently helped to shift their memories from the short-term storage of the hippocampus to the long-term storage of the prefrontal cortex.
UC Berkeley researchers say they will be conducting a sleep-enhancing study similar to the above-mentioned electrical stimulation project in older adults to see if it will improve their overnight memory.
"Can you jumpstart slow wave sleep and help people remember their lives and memories better? It's [definitely] an exciting possibility," added Mander.